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Apexbio Technology LLC AZ3146 1124329-14-1 100mg
Supplier: Apexbio Technology LLC A8372100
AZ3146 (CAS 1124329-14-1) is a potent and selective inhibitor of monopolar spindle 1 (Mps1) kinase exhibiting an IC50 of 35 nM Mps1 kinase is crucial for various stages of mitosis including chromosome attachment and centrosome function and is involved in multiple post-mitotic signaling pathways In cell-based studies AZ3146 disrupts chromosome alignment and alters spindle assembly checkpoint activity by interfering with the recruitment of spindle checkpoint proteins such as Mad1 and Mad2 to kinetochores This compound is widely utilized to investigate mitotic regulation and checkpoint signaling in cellular and animal models
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