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Apexbio Technology LLC AZ505 1035227-43-0 10mg
SDP

Supplier:  Apexbio Technology LLC B125510

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AZ505 (CAS 1035227-43-0) is a small molecule identified through high-throughput chemical screening as a potent and selective inhibitor of SET and MYND domain-containing protein 2 (SMYD2) a lysine methyltransferase AZ505 inhibits SMYD2 with an IC50 of 0 12 M and a Ki of 0 3 M It acts as a substrate-competitive inhibitor binding to the peptide substrate recognition pocket of SMYD2 rather than the cofactor site SMYD2 mediates methylation of both histone proteins (H2B H3 and H4) and non-histone substrates such as the tumor suppressors p53 and Rb AZ505 is valuable for investigating SMYD2 function and epigenetic regulatory mechanisms in cancer and other diseases

Catalog No. 50-000-92167


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