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Medchemexpress LLC AZ5576 | 2751721-40-9 | 99.9% | C21H24FN3O3 | 100 MG
Supplier: Medchemexpress LLC HY143584100MG
AZ5576 is a potent and highly selective CDK9 inhibitor with an IC50 of less than 5 nM. It works by inhibiting the phosphorylation of RNA polymerase II at Ser2, which in turn inhibits transcriptional elongation. This product can be used for research related to hematological malignancies.
- Potent and highly selective CDK9 inhibitor
- Inhibits phosphorylation of RNA polymerase II at Ser2
- Inhibits transcriptional elongation
- Reduces Mcl-1 and MYC mRNA and protein expressions
- Inhibits DNA synthesis in DLBCL cells
- Induces apoptosis in DLBCL cells
- Soluble in DMSO at 125 mg/mL (requires sonication)
- Appears as a white to off-white solid
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