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Medchemexpress LLC Azd-1480 | 935666-88-9 | MFCD16038904 | 99.9% | 348.76 g/mol | C14H14ClFN8 | 100 MG
Supplier: Medchemexpress LLC HY10193100MG
AZD-1480 is a small-molecule, ATP-competitive inhibitor of Janus kinases JAK1 and JAK2 developed for research use to block JAK/STAT signaling. It exhibits potent biochemical inhibition of JAK2 and reduces STAT3 phosphorylation in cellular models, producing antiproliferative effects in JAK-dependent cell lines.
- ATP-competitive inhibitor of JAK1 and JAK2.
- High biochemical potency (JAK2 Ki ≈ 0.26 nM; JAK1 IC50 ≈ 1.3 nM reported).
- Inhibits STAT3 phosphorylation and downstream signaling in cells.
- Demonstrates antiproliferative activity in JAK-dependent cell models.
- Supplied as a high-purity research compound for in vitro and in vivo studies.
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