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Medchemexpress LLC AZD-7762 | 860352-01-8 | 99.9% | 362.42 | 25 MG
Supplier: Medchemexpress LLC 25MGHY10992
AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor, equally potent for Chk1 (IC50 of 5 nM) and Chk2 in vitro. It abrogates DNA damage-induced S and G2 checkpoints, modulates downstream checkpoint pathway proteins, and is shown to abrogate G2 arrest induced by Camptothecin.
- Potent ATP-competitive checkpoint kinase (Chk) inhibitor.
- IC50 of 5 nM for Chk1.
- Equally potent inhibitor of Chk1 and Chk2 in vitro.
- Abrogates DNA damage-induced S and G2 checkpoints.
- Enhances the efficacy of NSC 613327 and SKF 104864A.
- Modulates downstream checkpoint pathway proteins.
- Binds in the ATP-binding site of Chk1, competing directly for ATP binding in a reversible manner.
- Abrogates the G2 arrest induced by camptothecin.
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