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Apexbio Technology LLC AZD5363 1143532-39-1 25mg
Supplier: Apexbio Technology LLC A138725
AZD5363 (CAS 1143532-39-1) is a small-molecule inhibitor targeting the phosphatidylinositol-3-kinase (PI3K)/Akt signaling cascade It exhibits inhibitory activity against Akt with an approximate IC50 of 200 nM In preclinical studies AZD5363 hinders proliferation across multiple human cancer cell lines including castration-resistant prostate cancer (CRPC) cells where it induces apoptosis indicated by enhanced caspase-3 activation and PARP cleavage Furthermore AZD5363 treatment prompts cellular clusterin expression and autophagy a potential adaptive resistance mechanism to Akt inhibition As such AZD5363 represents a significant research tool for investigating PI3K/Akt signaling in cancer biology
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