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Cayman Chemical BacterIa FR900359 500ug
Supplier: Cayman Chemical 33666500 UG
A cyclic depsipeptide that has been found in A. crenata and is an inhibitor of Gαq, Gα11, and Gα14 (IC50s = 13.18, 10.47, and 10 nM, respectively); selective for these Gα subunits over a panel of additional Gα subunits over a panel of additional Gα subunits, including Gαs and Gαi, in BRET assays at 1 µM; induces relaxation of precontracted isolated mouse tail arteries and inhibits U-46619-induced platelet aggregation in washed isolated human platelets cultured with aspirin; induces cell cycle arrest at the G1 phase and reduces proliferation and serum-induced migration of B16 melanoma cells; inhibits airway hyperresponsiveness in a mouse model of house dust mite-induced allergic asthma at 2.5 UG/animal
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