Apexbio Technology LLC Bafetinib (INNO-406) 887650-05-7 100mg

Supplier:  Apexbio Technology LLC B1011100

Bafetinib (INNO-406 CAS 887650-05-7) is a selective dual inhibitor of Bcr-Abl and Lyn tyrosine kinases It demonstrates potent inhibition of Bcr-Abl (IC50 5 8 nM) and Lyn (IC50 19 nM) and suppresses Bcr-Abl autophosphorylation Bafetinib exhibits activity against Bcr-Abl-expressing cell lines such as K562 and 293T (IC50 11 nM and 22 nM respectively) and inhibits the proliferation of Bcr-Abl-positive leukemia cells including those harboring certain resistance mutations (e g M244V G250E Y253F F317L) but is inactive against T315I mutants In mouse tumor models bafetinib effectively suppresses tumor growth This compound is valuable in leukemia research particularly for studies on Bcr-Abl kinase inhibition and resistance mechanisms

Catalog No. 50-000-94043