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Medchemexpress LLC Baricitinib | 1187594-09-7 | C16H17N7O2S | 25 MG
Supplier: Medchemexpress LLC 25MGHY15315R
Baricitinib is a selective and orally bioavailable JAK1 and JAK2 inhibitor. This analytical standard is intended for research and analytical applications.
- Targets JAK2 (IC50: 5.7 nM) and JAK1 (IC50: 5.9 nM).
- Inhibits IL-6-stimulated phosphorylation of STAT3 (pSTAT3) and MCP-1 production in cell-based assays.
- Inhibits IL-23-stimulated pSTAT3 in isolated naive T-cells, preventing IL-17 and IL-22 production.
- In vivo, 1 mg/kg inhibits increases in hind paw volumes by 50%.
- Reduces inflammation, CD8 infiltration, and MHC class I and II expression in alopecia areata models.
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