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Medchemexpress LLC Baricitinib | 1187594-09-7 | C16H17N7O2S | 500 MG
Supplier: Medchemexpress LLC HY15315500MG
Baricitinib is a selective and orally bioavailable inhibitor of JAK1 and JAK2. This compound is intended for research applications, facilitating studies in inflammation and immunology.
- Selective and orally bioavailable JAK1 and JAK2 inhibitor
- IC50s of 5.9 nM for JAK1 and 5.7 nM for JAK2
- Molecular weight: 371.42
- Appearance: Solid
- Color: White to off-white
- Melting/freezing point: 212-215°C
- Relative density: 1.56 g/cm³
- Inhibits IL-6 induced MCP-1 production in peripheral blood mononuclear cells (IC50 40 nM)
- Inhibits pSTAT3 stimulated by IL-23 in isolated naive T-cells (IC50 20 nM)
- Prevents production of IL-17 and IL-22 by Th17 cells (IC50 50 nM)
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