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Medchemexpress LLC Basimglurant | 802906-73-6 | C18H13ClFN3 | 500 MG
Supplier: Medchemexpress LLC HY15446500MG
Basimglurant is a selective, orally active, and blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). It effectively inhibits mGlu5-mediated signaling pathways, regulating dopamine levels in the nucleus accumbens. Basimglurant has shown anxiolytic, antidepressant-like, analgesic, and arousal-promoting effects, and is used in research for depression, fragile X syndrome, and anxiety disorders.
- Potent mGlu5 inhibitor with good oral bioavailability.
- Long half-life, supporting once-daily administration.
- Good brain penetration and high in vivo potency.
- Exhibits antidepressant properties and anxiolytic-like features.
- Undergoing phase II clinical studies for depression and fragile X syndrome.
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