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Cayman Chemical BAY-2416964 25mg
Supplier: Cayman Chemical 3693925 MG
An AhR antagonist (IC50 = 22 nM in U87 cells); decreases kynurenic acid-induced mRNA expression of CYP1A1 and AHRR in LPS-stimulated isolated human monocytes at 100 nM; increases CD3-, CD28-, and IL-2-induced IFN-γ production in isolated human naïve CD4+ T cells from 30-1,000 nM; reduces tumor volume, increases CD8+ T cell and NK cell tumor infiltration, and decreases GR1+ myeloid cell and CD206+ M2 macrophage tumor infiltration in a B16/F10-OVA murine melanoma model at 30 mg/kg, p.o.
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