Cayman Chemical BAY 60-2770 5mg

Supplier:  Cayman Chemical 200775 MG

An activator of soluble guanylate cyclase (EC50s = 592 and 573 nM for the α1β1 and α2β1 isoforms, respectively); increases cGMP levels in, and inhibits the aggregation of, collagen- or thrombin-activated washed isolated human platelets, effects that can be potentiated by ODQ; inhibits doxorubicin-induced decreases in the viability of, and increases in ROS levels in, H9c2 cardiomyocytes at 10 µM; decreases pulmonary and systemic arterial pressure in a rat model of monocrotaline-induced pulmonary hypertension; reduces BALF and lung tissue eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic airway inflammation at 1 mg/kg; reverses obesity-induced increases in the frequency of voiding and non-voiding bladder contractions in mice fed a high-fat diet at 1 mg/kg

Catalog No. 50-298-3095