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Medchemexpress LLC Bay 61-3606 hydrochloride | 1615197-10-8 | 98.1% | C20H19ClN6O3 | 25 MG
Supplier: Medchemexpress LLC 25MGHY76474A
BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible, and highly selective Syk inhibitor, with a Ki of 7.5 nM and an IC50 of 10 nM. It reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells and decreases Syk phosphorylation in K-rn cell lysates. Additionally, it sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
- Orally available and ATP-competitive.
- Reversible and highly selective Syk inhibitor.
- Reduces ERK1/2 and Akt phosphorylation in neuroblastoma cells.
- Induces a large decrease of Syk phosphorylation in K-rn cell lysates.
- Sensitizes TRAIL-induced apoptosis in breast cancer cells.
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