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Medchemexpress LLC BAY-707 | 2109805-96-9 | 99.6% | 288.34 | 100 MG
Supplier: Medchemexpress LLC HY112081100MG
BAY-707 is a chemical probe and a substrate-competitive, highly potent, and selective inhibitor of MTH1 (NUDT1) with an IC50 of 2.3 nM. It exhibits a favorable pharmacokinetic (PK) profile compared to other MTH1 compounds and is well-tolerated in mice, but it lacks in vitro or in vivo anticancer efficacy.
- Highly potent and selective MTH1 (NUDT1) inhibitor: IC50 of 2.3 nM.
- Good pharmacokinetic (PK) profile compared to other MTH1 compounds.
- Well-tolerated in mice with no significant body weight loss observed.
- Superior cellular target engagement with an EC50 of 7.6 nM.
- High cell permeability in Caco-2 assay with an efflux ratio of 288 nm/s.
- Favorable physicochemical profile and promising in vitro pharmacokinetic properties with high metabolic stability in human microsomes and rat hepatocytes.
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