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Medchemexpress LLC BAY-899 | 2471967-92-5 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HY13024850MG
BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist, functioning as a chemical probe. It demonstrates IC50s of 185 nM for human LH (hLH) and 46 nM for rat LH (rLH), and is capable of reducing sex hormone levels. In vivo studies have shown that BAY-899 can reduce serum estradiol levels in intact female rats and exhibits a half-life of approximately 11-12 hours in Wistar rats.
- Orally active and selective luteinizing hormone receptor (LH-R) antagonist
- IC50s of 185 nM for human LH (hLH) and 46 nM for rat LH (rLH)
- Capable of reducing sex hormone levels
- Inhibits human ERG expressed in HEK293 cells with an IC50 of 10.6 μM
- Reduced serum estradiol levels in intact female rats
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