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Medchemexpress LLC BAY-9835 | 3032487-31-0 | 99.5% | 493.39 | 25 MG
Supplier: Medchemexpress LLC 25MGHY162284
BAY-9835 is a chemical probe and an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. It shows inhibitory potencies against mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is highly selective against various off-targets and metalloproteases and can be used for the study of atherogenesis.
- IC50s of 6 nM for ADAMTS7 and 30 nM for ADAMTS12.
- Inhibitory potencies against mouse (8 nM) and rat (27 nM) ADAMTS7 enzymes.
- High selectivity against off-targets and metalloproteases.
- High metabolic stability with human microsomes.
- No inhibition of CYP1A2, 2C8, 2C9, 2D6, and 3A4 enzymes or cardiac ion channels (< 20 μM).
- Well tolerated in mice with no adverse effects at 50 mg/kg.
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