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Medchemexpress LLC BAY885 | 2307249-33-6 | 99.3% | 515.53 | 1 ML
Supplier: Medchemexpress LLC HY11208210MM/1ML
BAY885 is a chemical probe, characterized as a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. It exhibits weak inhibition on other kinases.
- Highly potent and selective ERK5 inhibitor.
- Exhibits an IC50 of 35 nM for ERK5.
- Shows weak inhibition on other kinases.
- The ERK5 probe 41 demonstrated potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM).
- No effects observed on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM).
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