Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Bazedoxifene HCl 198480-56-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B15195.1
Bazedoxifene HCl (198480-56-7) is a non-steroidal selective estrogen receptor modulator (SERM) targeting estrogen receptor subtypes ER and ER It is designed to bind ERs thereby modulating estrogen receptor-mediated signaling pathways Bazedoxifene HCl exerts its biological activity primarily by antagonizing ER -mediated transcriptional activity thereby inhibiting estradiol-induced cell proliferation In cell-based studies Bazedoxifene HCl demonstrates inhibition of cell proliferation in human breast cancer (MCF-7) ovarian (CHO) hepatic (HepG2) and neuronal (GT1-7) cell lines The compound exhibits binding affinities (Ki) of 26 nM for ER and 99 nM for ER Based on these pharmacological properties Bazedoxifene HCl holds research potential in osteoporosis and estrogen receptor-mediated diseases including breast ovarian and uterine cancers
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?