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Cayman Chemical BB-Cl-Amidine, 1802637-39-3, 5 mg
Supplier: Cayman Chemical 170795
A PAD inhibitor; a modified version of Cl-amidine; irreversibly inactivates all four PAD subtypes (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively); potency is increased 20-fold over that of Cl-amidine (EC50 = 8.8 µM versus >200 µM for Cl-amidine); longer half-life than Cl-amidine (1.75 h versus ~15 min, respectively); inhibits formation of neutrophil extracellular traps
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