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Creative Biomart Belatacept
Supplier: Creative Biomart THP0102
The product is a soluble fusion protein which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge CH2 and CH3 domains) portion of human immunoglobulin G1 (IgG1) Structurally the product is a glycosylated fusion protein with a MALDI-MS molecular weight of 92 300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each It is produced through recombinant DNA technology in mammalian CHO cells The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes
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