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Medchemexpress LLC Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethy-1)- | 345303-91-5 | 98.2% | 455.46 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY19427A

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AZD9056 hydrochloride is a selective and orally active inhibitor of P2X7, a receptor that plays a significant role in inflammatory and pain-causing diseases. This compound is intended for research use only.

  • Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell lines, demonstrating high selectivity for the P2X7 receptor.
  • Exhibits an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
  • Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
  • Displays pain-relieving and anti-inflammatory effects.
  • Reverses the upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) induced by MIA in cartilage tissues.

Catalog No. 50-003-85590


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