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Medchemexpress LLC Benzeneacetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]- | 3025286-00-1 | 99.1% | 826.92 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY162307

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Nrf2 degrader 1 is a PROTAC Nrf2 degrader with a DC50 of 0.1-1 μM in huH1 cells. It inhibits cancer cell growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively. This compound is used for the study of liver cancer, non-small cell lung cancer (NSCLC), and squamous cell carcinoma of lung cancer. The chemical structure involves an Nrf2 Target protein ligand, a Cereblon ligand, and a linker.

  • Inhibits cancer cell viability with IC50 values of 100 nM for A549 cells and 40 nM for LK-2 cells
  • Composed of an Nrf2 target protein ligand, a Cereblon ligand (HY-41547), and a linker
  • Used in the study of liver cancer, non-small cell lung cancer, and squamous cell carcinoma of lung cancer
  • For research use only

Catalog No. 50-003-94384


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