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Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY17406650MG

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SI-W052 is an orally active, brain-penetrant, and selective small-molecule inhibitor targeting mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, thereby suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer's disease (AD)-associated neuroinflammation.

  • Orally active
  • Brain-penetrant
  • Selective small-molecule inhibitor targeting mTOR and TEX264
  • Activates autophagy by inhibiting mTOR phosphorylation
  • Enhances TEX264 expression to promote ER turnover
  • Suppresses LPS-induced release of inflammatory factors (TNF-α, IL-6)
  • Promising for research of Alzheimer's disease (AD)-associated neuroinflammation

Catalog No. 50-003-83985


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