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Medchemexpress LLC Berberine (chloride hydrate) | 68030-18-2 | 99.69% | 389.83 | 1 G
Supplier: Medchemexpress LLC HY175771G
Berberine chloride hydrate is an alkaloid that acts as an antibiotic. It induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. It also possesses antineoplastic properties.
- Acts as an antibiotic.
- Induces reactive oxygen species (ROS) generation.
- Inhibits DNA topoisomerase.
- Has antineoplastic properties.
- Shows potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines in vitro.
- Induces a time- and dose-dependent inhibition of LoVo cell growth.
- Exposure to 40 μM induces G2/M-phase cell cycle arrest in LoVo cells.
- Suppresses cyclin B1, cdc2, and cdc25c protein expression in LoVo cells.
- Inhibits the growth of human colorectal adenocarcinoma in vivo at doses of 30 and 50 mg/kg/day.
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