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Medchemexpress LLC Berberine (hemisulfate) | 316-41-6 | 384.40 | 50 MG
Supplier: Medchemexpress LLC HYN0716A50MG
Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). It is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate is noted for its anti-inflammatory, antibiobic, antitumor, cardiovascular protective, and neuroprotective activities.
- Anti-inflammatory activity: It inhibits TNF-α and the activation of its downstream pathways AP-1 and NF-κB.
- Antimicrobial activity: It works by inhibiting the bacterial cell division protein FtsZ or through DNA/RNA binding, leading to DNA/RNA damage.
- Neuroprotective efficacy: It protects against neurodegeneration by inhibiting reactive oxygen species (ROS) production and caspase activation, while activating the PI3K/Akt signaling pathway and heme oxygenase-1 (HO-1) expression.
- Metabolic disease attenuation: It helps to attenuate metabolic diseases by regulating lipid composition and inhibiting insulin resistance.
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