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Medchemexpress LLC Berubicin (RTA 744 free base) | 677017-23-1 | 87.8% | 633.64 | 5 MG
Supplier: Medchemexpress LLC HY149425MG
Berubicin is a doxorubicin analog that can cross the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). This compound exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells, making it suitable for studies related to nervous system tumors.
- Inhibits P-gp and MRP1-mediated efflux.
- Suppresses glioblastoma multiforme (GBM).
- Activates nuclear factor κB (NF-κB) and induces apoptosis in leukemia and neuroblastoma cells.
- More effective than doxorubicin in inhibiting SH-SY5Y cell growth.
- Prolongs the survival time of intracranial orthotopic glioma models in mice.
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