Medchemexpress LLC Bi-4020 | 2664214-60-0 | 99.30% | 100 MG

Supplier:  Medchemexpress LLC HY129550100MG

BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It inhibits the triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM in BaF3 cell lines, as well as the double mutant EGFR del19 T790M and primary mutant EGFR del19 with an IC50 of 1 nM. It also shows activity against EGFR wt (IC50=190 nM).

• Inhibits triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines)
• Inhibits double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM)
• Shows activity against EGFR wt (IC50=190 nM)
• Exhibits high kinome selectivity
• Good DMPK properties
• Leads to tumor regressions in human PC-9 (EGFR del19 T790M C797S) triple mutant NSCLC xenograft model in mice

Catalog No. 50-003-42350