Medchemexpress LLC BI605906 | 960293-88-3 | 99.7% | 50 MG

Supplier:  Medchemexpress LLC HY1301950MG

BI605906 is identified as a chemical probe and a novel IKKβ inhibitor. It exhibits an IC50 value of 380 nM when tested with 0.1 mM ATP. This compound was developed by Boehringer Ingelheim. BI605906 is a selective inhibitor of IKKβ, with only the insulin-like growth factor 1 (IGF1) receptor showing inhibition among over 100 tested protein kinases. It can partially inhibit the IL-1-stimulated activation of IKKε/TBK1. Studies in primary mouse hepatocytes show that BI605906 strongly inhibits TNF-α-dependent expression of CINC-1/CXCL1, CXCL2, IL-1β, and IL-6.

• Novel IKKβ inhibitor
• IC50 value of 380 nM (at 0.1 mM ATP)
• Selective inhibitor of IKKβ
• Partially inhibits IL-1-stimulated activation of IKKε/TBK1
• Strongly inhibits TNF-α-dependent expression of CINC-1/CXCL1, CXCL2, IL-1β, and IL-6 in primary mouse hepatocytes

Catalog No. 50-003-39645