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Medchemexpress LLC Binimetinib | 606143-89-9 | 1 ML
Supplier: Medchemexpress LLC HY1520210MM/1ML
Binimetinib (MEK162) is an oral and selective MEK1/2 inhibitor with an IC50 of 12 nM. It demonstrates antiproliferative activity against various human cancer cell lines, including those with KRAS and NRAS mutations, and reduces disease severity in animal models.
- Oral and selective MEK1/2 inhibitor.
- Potently inhibits MEK with an IC50 of 12 nM.
- Blocks basal ERK phosphorylation in HRAS mutant cell lines.
- Exhibits antiproliferative activity against various KRAS and NRAS mutant human cancer cell lines.
- Reduces disease severity in animal models.
- Demonstrates enhanced efficacy when combined with other agents in animal models.
- Shows significant tumor growth reduction when combined with BEZ235.
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