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Sigma Aldrich Fine Chemicals Biosciences BioTracker QUMA 1 RNA G qu
Supplier: Sigma Aldrich Fine Chemicals Biosciences SCT056
RNA G-quadruplexes are formed by self-assembly of guanine-rich RNA stacks into stacked G-quartets. This can occur in protein-coding (mRNA) as well as non-coding (ncRNA) transcripts. There is growing evidence that RNA G-quadruplexes are involved in different biological functions telomere elongation DNA recombination transcription RNA post-transcriptional mechanisms (pre-mRNA processing mRNA turnover targeting and translation) and are associated with sevral human diseases.BioTrackerTMSYMBOL/TMSYMBOL QUMA-1 RNA G-quadruplex Live Cell Dye (QUMA-1) is a red-emitting fluorescent probe that can be used to study dynamics (folding and unfolding) and movements of RNA G-quadruplexes. QUMA-1 is a reversible dye that emits upon binding to G-quadruplexes and turns off upon unfolding. QUMA-1 is highly specific for RNA G-quadruplexes and does not bind to DNA double-stranded RNA single-stranded RNA or other RNA structures. QUMA-1 could also potentially be used to study RNA-protein interacti
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