Sigma Aldrich Fine Chemicals Biosciences BioTracker TiY Vimentin Li

Supplier:  Sigma Aldrich Fine Chemicals Biosciences SCT059

Vimentin is an intermediate filament protein which is upregulated in cells undergoing epithelial-to-mesenchymal transition (EMT) and hence is commonly used an EMT marker. Tumor initiating cells (TICs) have been implicated in clinical relapse and metastasis of a variety of epithelial cancers including lung cancer.BioTracker TiY Vimentin is a live cell fluorescent dye that selectively stains TICs over differentiated tumor cells or normal cells. TiY can be used for visualization and enrichment of functionally active TICs from patient tumors. TiY displays better selectivity for tumorigenic cells than a CD166 antibody and can be used for TiY-staining-based cell sorting for TICs in various types of cancer (lung CNS melanoma breast renal ovarian colon and prostate cancer). At high concentrations TiY shows selective anti-TIC activity over non-TIC and normal tissue cells.Spectral PropertiesAbsorbance 553 nmEmission 573 nmReferencesLee Y et al. Identification of Tumor Initiating Cells w

Catalog No. 50-290-6486