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Medchemexpress LLC Bisindolylmaleimide I | 133052-90-1 | 98.2% | 412.48 | 50 MG
Supplier: Medchemexpress LLC HY1386750MG
Bisindolylmaleimide I is a cell-permeable and reversible protein kinase C (PKC) inhibitor, identified with IC50 values for various PKC isoforms. It also acts as a glycogen synthase kinase-3 (GSK-3) inhibitor and is for research use only.
- Cell-permeable and reversible PKC inhibitor (IC50 for PKCα, PKCβI, PKCβII, PKCγ: 16-20 nM)
- GSK-3 inhibitor
- Inhibits human platelet aggregation
- Protects against *Bacillus anthracis* lethal toxin-mediated cytotoxicity
- Inhibits α-thrombin-induced P47 phosphorylation
- Reduces GSK-3 activity in adipocyte lysates
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances cytotoxicity of 5-fluorouracil
- Demonstrates *in vivo* activity in mice and shrews
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