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Medchemexpress LLC Bisindolylmaleimide I | 133052-90-1 | MFCD00236428 | 98.2% | 412.48 | 100 MG
Supplier: Medchemexpress LLC HY13867100MG
Bisindolylmaleimide I is a cell-permeable and reversible protein kinase C (PKC) inhibitor. It exhibits inhibitory activity against various PKC isoforms, including PKCα, PKCβI, PKCβII, and PKCγ. This compound also functions as a GSK-3 inhibitor, making it suitable for a range of research applications.
- Cell-permeable and reversible PKC inhibitor
- Inhibits PKCα with an IC50 of 20 nM
- Inhibits PKCβI with an IC50 of 17 nM
- Inhibits PKCβII with an IC50 of 16 nM
- Inhibits PKCγ with an IC50 of 20 nM
- Functions as a GSK-3 inhibitor
- Protects against *Bacillus anthracis* lethal toxin-mediated cytotoxicity
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances cytotoxicity of 5-fluorouracil
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