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Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | 448.94 | 100 MG
Supplier: Medchemexpress LLC HY13867A100MG
Bisindolylmaleimide I hydrochloride is a cell-permeable and reversible protein kinase C (PKC) inhibitor with IC50 values of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively. It also acts as a glycogen synthase kinase-3 (GSK-3) inhibitor, making it suitable for a wide range of research applications.
- Cell-permeable and reversible protein kinase C inhibitor
- Glycogen synthase kinase-3 inhibitor
- Inhibits α-thrombin-induced P47 phosphorylation
- Inhibits DNA synthesis in quiescent swiss 3T3 cells
- Reduces GSK-3 activity in adipocyte lysates
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances cytotoxicity of 5-fluorouracil
- Reduces increased NLRP3, P-PKCɑ, and PKCɑ levels in mechanical ventilation group
- Reduces Quinpirole-induced vomiting in shrews
- Blocks Quinpirole-mediated ERK1/2 phosphorylation in shrew brainstems
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