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Abcam Bisindolylmaleimide x I hydrochloride, PKC inhibitor, 5MG

Supplier:  Abcam AB1437835MG

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MW 489 Da, Purity >98%. Selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC₅₀ = 9 nM) and 4-fold greater selectivity for PKCβI (IC₅₀ = 28 nM) over Ca²+-independent PKCε (IC₅₀ = 108 nM). Enhances cardiac contractility and protection from heart failure. Prevents T-cell activation and proliferation (IC₅₀s ranging from 30-150 nM) associated with chronic inflammatory responses in vivo. Also inhibits GRK2, GRK5, and GRK6 (IC₅₀ values are 29, 3.6, and 16 μM, respectively).

The product is subject to the following: Abcam Restricted Use Statement

Catalog No. 50-270-6085


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