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Apexbio Technology LLC Bitopertin(Synonyms: RG1678, RO4917838, RG-1678, RO-4917838), 200mg, CAS: 845614-11-1.
Supplier: Apexbio Technology LLC A3242200
Bitopertin (CAS 845614-11-1) also known as RG1678 is a selective inhibitor of glycine transporter-1 (GlyT1) exhibiting an EC50 of 30 nM in vitro GlyT1 inhibition increases synaptic glycine a co-agonist at N-methyl-D-aspartate (NMDA) receptor glycine-binding sites thereby enhancing NMDA receptor-mediated glutamatergic neurotransmission This mechanism addresses glutamatergic dysfunction implicated in schizophrenia Clinical studies indicate that adjunctive bitopertin treatment improves negative symptoms in schizophrenia patients highlighting its therapeutic potential as a GlyT1-targeted research tool and drug candidate
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