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Apexbio Technology LLC BIX 01294 935693-62-2 5mg
Supplier: Apexbio Technology LLC A19095
BIX 01294 (CAS 935693-62-2) is a small molecule inhibitor identified through high-throughput screening of a synthetic compound library for its activity against G9a and GLP both H3K9-specific histone lysine methyltransferases BIX 01294 shows selectivity for G9a and GLP relative to other methyltransferases such as SUV39H1 ESET SET7/9 and the arginine methyltransferase PRMT1 Structural studies demonstrate that BIX 01294 binds to the histone peptide-binding pocket of GLP rather than the lysine channel In cell-based assays treatment with BIX 01294 at 4 1 M reduces levels of H3K9 dimethylation while higher concentrations induce cytotoxicity This compound is widely used as a chemical probe in studies of epigenetic regulation and gene expression
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