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Apexbio Technology LLC BKT140 664334-36-5 1mg
Supplier: Apexbio Technology LLC B78331
BKT140 (CAS 664334-36-5) also known as BL-8040 or TF 14016 is an orally bioavailable antagonist of the CXC chemokine receptor 4 (CXCR4) CXCR4 a G protein-coupled receptor mediates chemotaxis and angiogenesis and is often upregulated in various malignancies contributing to tumor progression and dissemination BKT140 disrupts CXCR4 signaling thereby inhibiting processes vital for tumor cell survival and metastasis In preclinical studies BKT140 reduced colony formation in non-small cell lung cancer cells delayed xenograft tumor growth and induced apoptosis in multiple myeloma lymphoma and leukemia models Additionally BKT140 promotes mobilization of hematopoietic stem and white blood cells supporting its utility in cancer and stem cell research
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