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FOCUS BIOMOLECULES BM30, NTMT1/2 peptidomimetic inhibitor, >95% by HPLC
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Supplier:  FOCUS BIOMOLECULES EI0101MG

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Biochemical Reagents, BM30, NTMT1/2 peptidomimetic inhibitor, >95% by HPLC, Sequence: XPKR-NH2 with X as 4-hydroxyphenylacetyl, C terminal amide; The first potent peptidomimetic inhibitor for N-terminal methyltransferase1/2 (NTMT1/2). BM30 has a half-maximal inhibitory concentration of 0.89 ± 0.10 μM, is a competitive inhibitor to the peptide substrate and is noncompetitive to the cofactor S-adenosylmethionine. BM30 exhibits over 100-fold selectivity for NTMT1/2 among a panel of 41 methyl transferases, showing great potential for high selectivity when targeting the peptide substrate binding site of NTMT1/2. Its cell-permeable analogue DC432 is also available, which can decrease the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells.

Catalog No. NC2600151


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