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Medchemexpress LLC BMH-21 | 896705-16-1 | 99.3% | 360.41 | C21H20N4O2 | 500MG
Supplier: Medchemexpress LLC HY12484500MG
BMH-21 is a planar heterocyclic small-molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I) transcription and demonstrates anticancer activity. It binds GC-rich ribosomal DNA, induces nucleolar stress, and promotes degradation of the Pol I subunit RPA194, resulting in suppression of ribosomal RNA synthesis. Supplied as a research-grade powder for in vitro and preclinical studies.
- DNA intercalator with preference for GC-rich sequences.
- Selective inhibitor of RNA polymerase I transcription.
- Induces nucleolar stress and promotes RPA194 degradation.
- High purity research-grade material suitable for biochemical studies.
- Supplied as a powder with recommended cold storage for stability.
- Commonly used in cancer biology and transcription research.
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