Medchemexpress LLC BMS-1166 | 1818314-88-3 | MFCD31746874 | ≥98.0% | 641.11 g·mol⁻¹ | C36H33ClN2O7 | 1 MG

Supplier:  Medchemexpress LLC HY1020111MG

BMS-1166 is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction used in preclinical immuno-oncology research. It binds PD-L1, induces PD-L1 dimerization, and blocks PD-1 binding, restoring T-cell activation in cellular assays. Reported identifiers include CAS 1818314-88-3, formula C36H33ClN2O7, and molecular weight 641.11 g·mol⁻¹.

• Potent PD-1/PD-L1 interaction inhibition with IC50 ≈ 1.4 nM.
• Demonstrated cellular activity (EC50 ≈ 276 nM in a Jurkat/CHO reporter assay).
• High purity suitable for research use (≥98%).
• Solid powder formulation, stored at -20°C for long-term stability.
• Commonly used for in vitro immune checkpoint blockade and preclinical assays.

Catalog No. 50-002-47533