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Medchemexpress LLC BMS-582949 hydrochloride | 912806-16-7 | 98.9% | C22H27ClN6O2 | 100 MG
Supplier: Medchemexpress LLC HY14305A100MG
BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor with an IC50 of 13 nM. It demonstrates a significantly improved pharmacokinetic profile and is effective in inflammatory diseases.
- Target: p38α MAPK (IC50: 13 nM), TNFα (IC50: 50 nM, in cells)
- Selectivity: exhibits >2000-fold selectivity for p38α over 57 diverse kinases
- In vivo efficacy: effective in both acute murine inflammation models and rat adjuvant arthritis models
- Orally active
- High selectivity for p38α MAPK
- Improved pharmacokinetic profile
- Effective in inflammatory diseases
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