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Medchemexpress LLC BMS-582949 hydrochloride | 912806-16-7 | 98.90% | C22H27ClN6O2 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14305A
BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor with an IC50 of 13 nM. It displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease. BMS-582949 is a weak inhibitor of CYP3A4 and displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases. In vivo, it is effective in both the acute murine model of inflammation and rat adjuvant arthritis model. Storage conditions: 4°C, sealed storage, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture).
- Orally active and highly selective p38α MAPK inhibitor
- Improved pharmacokinetic profile
- Effective in inflammatory disease
- Weak inhibitor of CYP3A4
- Displays >2000-fold selectivity for p38α over 57 kinases
- Effective in acute murine models of inflammation and rat adjuvant arthritis models
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