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Apexbio Technology LLC BMS-754807(Synonyms: BMS754807, IGF-1R/InsR inhibitor BMS-754807, IGF-1R Inhibitor BMS-754807, BMS 754807), 100mg, CAS: 1001350-96-4.
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Supplier:  Apexbio Technology LLC A1185100

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BMS-754807 (CAS 1001350-96-4) is a small molecule inhibitor targeting insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) Acting as an ATP-competitive antagonist it directly interferes with the catalytic kinase domains of IGF-1R/IR thereby disrupting their enzymatic activities In vitro studies demonstrated potent antiproliferative activity against various cancer cell lines including mesenchymal hematopoietic and epithelial tumors (IC50 ranging from 5 to 365 nmol/L) Furthermore evidence from apoptosis assays in human rhabdomyosarcoma cells indicates BMS-754807 can induce apoptosis characterized by increased caspase cleavage and poly(ADP-ribose) polymerase (PARP) fragmentation This compound is primarily applied in oncology research aimed at elucidating IGF-1R/IR signaling pathways

Catalog No. 50-000-60819


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