Apexbio Technology LLC BMS-794833 1174046-72-0 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B14385.1

BMS-794833 (CAS 1174046-72-0) is a small molecule inhibitor that acts as an ATP-competitive dual antagonist of c-Met and VEGFR2 exhibiting IC50 values of 1 7 nM and 15 nM respectively It also inhibits kinases such as Ron Axl and Flt3 with IC50 values below 3 nM BMS-794833 suppresses c-Met-mediated signaling in gastric cancer cell lines (GTL-16) with an IC50 of 39 nM and demonstrates greater than 50% tumor growth inhibition in gastric cancer xenograft models after a minimum of one tumor doubling time without significant toxicity over 14 days In glioblastoma (U87) models 25 mg/kg administration results in complete tumor growth arrest This compound supports research into tyrosine kinase signaling and targeted cancer therapies

Catalog No. 50-000-91615