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Medchemexpress LLC BMS-911543 | 1271022-90-2 | C23H28N8O | 2 MG
Supplier: Medchemexpress LLC HY152702MG
BMS-911543 is a highly selective JAK2 inhibitor with an IC50 of 1.1 nM. It demonstrates potent antiproliferative effects on JAK2-dependent SET-2 and BaF3-V617F engineered cell lines. This compound also selectively reduces pSTAT5 expression in pancreatic tumors and decreases intratumoral FoxP3+ T regulatory cells in mice, making it a relevant tool for research into myeloproliferative neoplasms and pancreatic cancer.
- Selective JAK2 inhibitor (IC50 1.1 nM)
- Potent antiproliferative effects on SET-2 and BaF3-V617F cells
- Reduces pSTAT5 expression in pancreatic tumors
- Decreases intratumoral FoxP3+ T regulatory cells
- Blocks T regulatory cell differentiation in vitro
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