Apexbio Technology LLC BMS265246 582315-72-8 5mg

Supplier:  Apexbio Technology LLC A83855

BMS265246 (CAS 582315-72-8) is a potent and selective inhibitor of cyclin-dependent kinases CDK1 and CDK2 demonstrating IC50 values of 6 nM and 9 nM respectively By targeting serine/threonine protein kinases central to cell cycle regulation BMS265246 disrupts CDK-cyclin signaling and effectively inhibits cell proliferation In cellular assays BMS265246 suppresses Cdk4/cycD activity and blocks proliferation in models such as A2780 Cytox cells (IC50 0 23 M and 0 76 M) and HCT-116 cells (EC50 0 293 0 492 M) Treatment induces G2 phase arrest enlarged nuclei and increases in 4N DNA content This compound is valuable for studying cell cycle dynamics and the pharmacology of CDK inhibition in cancer research

Catalog No. 50-000-96035