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Apexbio Technology LLC Boc-D-FMK 187389-53-3,634911-80-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A19045.1
Boc-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that functions by irreversibly binding to activated caspase enzymes blocking apoptotic signaling pathways Mechanistically Boc-D-FMK inhibits TNF- -induced apoptosis and attenuates downstream pro-inflammatory responses including reduced NF- B activation and decreased phosphorylation of I B Additionally this inhibitor suppresses adhesion molecule expression notably ICAM-1 and VCAM-1 mediated by TNF signaling Boc-D-FMK is frequently utilized in apoptosis and inflammation research including experimental models examining renal endothelial inflammation and hepatocyte apoptosis following bile duct obstruction
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