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AdipoGen Borrelidin,Chemical. CAS: 7184-60-3
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Supplier:  AdipoGen BVT0098M001

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Borrelidin, AdipoGen Life Sciences. Chemical. CAS: 7184-60-3. Formula: C28H43NO6. MW: 489.6. Isolated from Streptomyces sp. Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Potent antimalarial agent (IC50 = 0.97 nM). Inhibitor of potato scab disease.

Catalog No. 50-464-845


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